Evidence of in vivo existence of Borrelia biofilm in borrelial lymphocytomas

Lyme borreliosis, caused by the spirochete Borrelia burgdorferi sensu lato, has grown into a major public health problem. We recently identified a novel morphological form of B. burgdorferi, called biofilm, a structure that is well known to be highly resistant to antibiotics. However, there is no evidence of the existence of Borrelia biofilm in vivo; therefore, the main goal of this study was to determine the presence of Borrelia biofilm in infected human skin tissues. In summary, this is the first study that demonstrates the presence of Borrelia biofilm in human infected skin tissues."
*Corresponding author: Eva Sapi; 300 Boston Post Road, West Haven CT 06516, USA; Phone: +1-203-479-4552, E-mail: esapi@newhaven.edu
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