Bacterial resistance to antibiotics is a problem, and according to this recent study published in the journal Royal Society Interface, using three drug combinations can help counter antibiotic resistance

Bacterial resistance to antibiotics is a problem, and according to this recent study published in the journal Royal Society Interface, using three drug combinations can help counter antibiotic resistance. Even though borrelia has been shown to create drug tolerant persister cells and NOT antibiotic resistant mutants (Borrelia burgdorferi, the causative agent of Lyme disease, forms drug-tolerant persister cells. Sharma B, Brown AV, Matluck NE, Hu LT, Lewis K.Antimicrobial Agents And Chemotherapy, pii: AAC.00864-15. Online first, 2015 May 26), we regularly combine multiple combinations of agents to address the cell wall, cystic, and intracellular forms of borrelia, as well as those in biofilms. The recent Dapsone and pyrazinamide studies that we published in the medical literature found that combining multiple intracellular antibiotics (at least 3 at once), especially using "persister" antibiotics like those used for mycobacterium infections, were effective in a large percentage of those failing traditional therapies. This was especially helpful in sick patients when there were multiple intracellular co-infections (llike Bartonella, tularemia...) while overlapping medical problems on the 16 point MSIDS model were adequately addressed. Prospective studies need to be done to evaluate the best combinations of antibiotics and biofilm busters for borreliosis and tick-borne co-infections. Thanks to a grant from the Lyme Navigator Foundation, Dr Eva Sapi and I will be looking at these combinations later this year.


https://www.sciencedaily.com/releases/2016/07/160722104140.htm