Lyme is much more than Lyme alone.
In the holistic management of Lyme, there are many factors that can lead to significant improvements besides addressing the microbes, especially in those who are non-responsive to antibiotics. Some of most common, but overlooked, factors that I see are addressing parasites, osteonecrosis of the jaw (cavitations), root canals, dental amalgams, mycotoxins, and food sensitivities. Addressing these issues removes the burden on the immune system so that the body can better handle the microbes.