Eradication of Biofilm-Like Microcolony Structures of Borrelia burgdorferi by Daunomycin and Daptomycin but not Mitomycin C in Combination with Doxycycline and Cefuroxime
Dr Zhang and colleagues from Johns Hopkins University just published an article on combinations of antibiotics against borrelia biofilm like microcolonies. "The two drug combination of doxycycline and cefuroxime was unable to eradicate biofilm-like microcolonies of B. burgdorferi persisters. However, the addition of either daunomycin or daptomycin to the doxycycline + cefuroxime combination completely eradicated the biofilm-like structures and produced no visible bacterial regrowth after 7 and 21 days". This article confirms that usual drug regimens against borrelia are unable to completely eradicate persister bacteria (which clinicians who treat Lyme have known for years), and that a persister drug like daptomycin is necessary to decrease regrowth of the bacteria. The problem with using Daptomycin in clinical practice is that drug must be administered by IV route and is very expensive. I am in the process of evaluating the use of oral generic drugs with persister properties in our medical practice, and the initial statistical data is encouraging. I have been in contact with Dr Zhang, and we submitted a grant to do a prospective study with John Hopkins on novel persister drugs in Lyme disease. We also just received an invitation to submit our initial data for publication, and I am in the process of reviewing the data and statistics with Dr Phyllis Freeman, the PhD researcher at our practice. I hope to have encouraging results for everyone in the near future!
Lyme disease, caused by Borrelia burgdorferi, is the most common vector-borne disease in the United States and Europe. While the majority of Lyme disease patients can resolve their symptoms if treated promptly, 10-20% of patients suffer from prolonged symptoms called post-treatment Lyme disease synd…