Bacterial
resistance to antibiotics is a problem, and according to this recent
study published in the journal Royal Society Interface, using three drug
combinations can help counter antibiotic resistance. Even though
borrelia has been shown to create drug tolerant persister cells and NOT
antibiotic resistant mutants (Borrelia burgdorferi, the causative agent
of Lyme disease, forms drug-tolerant persister cells. Sharma B, Brown
AV, Matluck NE, Hu LT, Lewis K.Antimicrobial Agents
And Chemotherapy, pii: AAC.00864-15. Online first, 2015 May 26), we
regularly combine multiple combinations of agents to address the cell
wall, cystic, and intracellular forms of borrelia, as well as those in
biofilms. The recent Dapsone and pyrazinamide studies that we published
in the medical literature found that combining multiple intracellular
antibiotics (at least 3 at once), especially using "persister"
antibiotics like those used for mycobacterium infections, were effective
in a large percentage of those failing traditional therapies. This was
especially helpful in sick patients when there were multiple
intracellular co-infections (llike Bartonella, tularemia...) while
overlapping medical problems on the 16 point MSIDS model were adequately
addressed. Prospective studies need to be done to evaluate the best
combinations of antibiotics and biofilm busters for borreliosis and
tick-borne co-infections. Thanks to a grant from the Lyme Navigator
Foundation, Dr Eva Sapi and I will be looking at these combinations
later this year.
https://www.sciencedaily.com/releases/2016/07/160722104140.htm
https://www.sciencedaily.com/releases/2016/07/160722104140.htm
