Atteinte de la borréliose chronique persistante , babesia et bartonella ; le déni est grand , battons nous pour la faire connaitre la borréliose de lyme et ses coinfections ; 8 ans de bi et tri therapies d'antibiotiques auxquels j'ai ajouté une partie du protocole Buhner et autres http://francelyme.fr
If You Think Lyme is Bad, Meet Babesia !
[This
is part 1 of my 2 part series on Babesia. This one is intended to help
you recognize it, and part 2 will address treatment options.] Would you
tell a friend or...
suzycohen.com
This scientific article follows up on the research done by Dr Zhang at Johns Hopkins discussing Borrelia burgdorferi causing drug-tolerant persister cells. As per Dr Sharma and Dr Hu: "In other chronic infections, the presence of drug-tolerant persisters has been linked to recalcitrance of the disease. In this study, we examined the ability of B. burgdorferi to form persisters. Killing of growing cultures of B. burgdorferi with antibiotics used to treat the disease was distinctly biphasic, with a small subpopulation of surviving cells. Upon regrowth, these cells formed a new subpopulation of antibiotic-tolerant cells, indicating that these are persisters rather than resistant mutants. The level of persisters increased sharply as the culture transitioned from exponential to stationary phase. Combinations of antibiotics did not improve killing.
Daptomycin, a membrane-active bactericidal antibiotic, killed stationary phase cells, but not persisters. Mitomycin C, an anti-cancer agent that forms adducts with DNA, killed persisters and eradicated both growing and stationary cultures of B. burgdorferi. Finally, we examined the ability of pulse-dosing an antibiotic to eliminate persisters. After addition of ceftriaxone, the antibiotic was washed away, surviving persisters were allowed to resuscitate, and antibiotic was added again. Four pulse-doses of ceftriaxone killed persisters, eradicating all live bacteria in the culture".
This article implies that pulse dose antibiotics with Daptomycin, Mitomycin and Rocephin may be helpful in culture. Limitations of this research includes the choice of medications used, as well as not being an in vitro study. Other limitations include Mitomycin being a cancer drug not commonly used in Lyme disease and the study doesn't address bacteria that are difficult to kill in the intracellular compartment, in biofilm colonies and in cystic forms, or those bacteria that may be deep in tissues where antibiotics don't penetrate well. This is an encouraging study however, as researchers are finally admitting that persister cells exist in Lyme disease as they do in other chronic infectious diseases. Co-infections, such as Babesia, Bartonella were also not addressed in this study, and the majority of my patients who are chronically ill have multiple overlapping co-infections, and improve once those co-infections are adequately treated. Further studies are needed to evaluate combination and pulse therapies in Lyme disease, as well as evaluating combination therapies for associated co-infections.
Daptomycin, a membrane-active bactericidal antibiotic, killed stationary phase cells, but not persisters. Mitomycin C, an anti-cancer agent that forms adducts with DNA, killed persisters and eradicated both growing and stationary cultures of B. burgdorferi. Finally, we examined the ability of pulse-dosing an antibiotic to eliminate persisters. After addition of ceftriaxone, the antibiotic was washed away, surviving persisters were allowed to resuscitate, and antibiotic was added again. Four pulse-doses of ceftriaxone killed persisters, eradicating all live bacteria in the culture".
This article implies that pulse dose antibiotics with Daptomycin, Mitomycin and Rocephin may be helpful in culture. Limitations of this research includes the choice of medications used, as well as not being an in vitro study. Other limitations include Mitomycin being a cancer drug not commonly used in Lyme disease and the study doesn't address bacteria that are difficult to kill in the intracellular compartment, in biofilm colonies and in cystic forms, or those bacteria that may be deep in tissues where antibiotics don't penetrate well. This is an encouraging study however, as researchers are finally admitting that persister cells exist in Lyme disease as they do in other chronic infectious diseases. Co-infections, such as Babesia, Bartonella were also not addressed in this study, and the majority of my patients who are chronically ill have multiple overlapping co-infections, and improve once those co-infections are adequately treated. Further studies are needed to evaluate combination and pulse therapies in Lyme disease, as well as evaluating combination therapies for associated co-infections.
I blogged about my experience last week with my heart stopping. This Lyme is a vicious beast
https://kamilingren.wordpress.com/2015/05/28/the-moment-lyme-took-my-breath-away/
"this is probably my least flowery post ever, but I care way too much about my fellow man to be silent about my suffering – if I can spare another person from living this nightmare, I will. I won’t keep my voice quiet, no matter how many doctors cause me to cry over standing up for myself and my health. no matter how many people look at me like I’m making up every symptom I daily fight for my life through. no matter how many years us Lymies wait and fight for change in the system. I’ll still be here, as long as God allows, fighting for change however my body is able."
Opossums: The Unsung Heroes Against Lyme Disease And Other Tick-Borne Diseases
Several
states in the U.S. are reporting record populations of ticks and
increasing tick-borne disease transmission, like Lyme disease, but
clearing your yard
inquisitr.com
- Several states in the U.S. are reporting record populations of ticks and increasing tick-borne disease transmission, like Lyme disease, but clearing your yard of these blood suckers might be only one opossum away. Yes, that giant rat-looking animal that plays dead when threatened and hisses like the devil’s spawn when scared is actually extremely beneficial to humans and other mammals. Opossums’ diets include snakes, snails, slugs, mice, rats, and carrion.
Perhaps the most intriguing item on an opossum’s daily menu is an even more dreaded human foe: the tick. Opossums’ voracious appetite for ticks can nearly obliterate a tick population.
“So these opossums are walking around the forest floor, hoovering up ticks right and left,” Ostfeld explained, “killing over 90% of these things, and so they are really protecting our health.”
NFL Football team the Jacksonville Jaguars kindly accepted the #LymeDiseaseChallenge today by local children who have family members impacted by Lyme Disease.
NFL Football team the Jacksonville Jaguars kindly accepted the #LymeDiseaseChallenge today by local children who have family members impacted by Lyme Disease.
Facebook: https://www.facebook.com/jacksonvillejaguars/photos/a.420041703862.196379.89095583862/10153089134028863/?type=1&theater
Twitter:
https://twitter.com/Jaguars/status/603973184539463682
Facebook: https://www.facebook.com/jacksonvillejaguars/photos/a.420041703862.196379.89095583862/10153089134028863/?type=1&theater
Twitter:
https://twitter.com/Jaguars/status/603973184539463682
“Following today's practice, the #Jaguars took part in the #LymeDiseaseChallenge!”
twitter.com|Par Jacksonville Jaguars
Bay Area Lyme Foundation's LymeAid® Brings Celebrities and Scientists Together To Help...
David and Yolanda Foster, Daryl Hall, Huey Lewis, Jane Seymour and Elet Hall are among supporters.
prohealth.com
Life with Lyme: Woman struggles with disease
“It’s like an uphill marathon, blindfolded,” says Mauryah Burattini.
wellandtribune.ca|Par nurun.com
Former CDC Director Julie Gerberding sells 38,368 shares of Merck Stock for $2.3 Million
Julie Gerberding was in charge of the Centers for Disease Control and Prevention (CDC) from 2002 to...
healthimpactnews.com
Just finished my presentation at the 2015 ILADS conference (Interational Lyme and Associated Diseases Society) in Augsburg, Germany.
Yolanda Foster Refuses To Give Up During Lyme Disease Battle,
Yolanda Foster shared an inspiring message about her Lyme disease struggle on Sunday.
inquisitr.com
Lyme disease still a risk in 'low-risk' areas
Fatigue,
headaches, fever, muscle chills —they're all symptoms you may have had
with several kinds of illnesses. But ahead of the summer season, these
symptoms could be a sign of lyme disease.
wpsdlocal6.com|Par Amanda Roberts, Randall Barnes
Forgotten Plague is the story of an afflicted journalist who embarks on a journey to find out why the CDC and medical system have neglected his disease,
Forgotten
Plague is the story of an afflicted journalist who embarks on a journey
to find out why the CDC and medical system have neglected his disease,
leav...
The New England Journal of Medicine presents a case of a girl with loss of consciousness and a seizure due to #Bartonella encephalopathy.
The New England Journal of Medicine presents a case of a girl with loss of consciousness and a seizure due to #Bartonella
encephalopathy. The discussion focuses on the difficulty of PCR
detection and evaluation of antibody titers. Galaxy’s Bartonella ePCR™
technology increases sensitivity and specificity of DNA detection by up
to 10 times.
In
the latest Case Record of the Massachusetts General Hospital, a
9-year-old girl presented to the emergency department with loss of
consciousness and a
blogs.nejm.org
Neuroinvasion by Mycoplasma pneumoniae in acute disseminated encephalomyelitis.
Abstract
We report the autopsy findings for a 45-year-old man with polyradiculoneuropathy and fatal acute disseminated encephalomyelitis after having Mycoplasma pneumoniae pneumonia. M. pneumoniae antigens were demonstrated by immunohistochemical analysis of brain tissue, indicating neuroinvasion as an additional pathogenetic mechanism in central neurologic complications of M. pneumoniae infection.
We report the autopsy findings for a 45-year-old man with polyradiculoneuropathy and fatal acute disseminated encephalomyelitis after having Mycoplasma pneumoniae pneumonia. M. pneumoniae antigens were demonstrated by immunohistochemical analysis of brain tissue, indicating neuroinvasion as an additional pathogenetic mechanism in central neurologic complications of M. pneumoniae infection.
Emerg Infect Dis. 2008 Apr;14(4):641-3. doi: 10.3201/eid1404.061366. Case Reports
ncbi.nlm.nih.gov|Par Stamm B , et al.
This new immunostaining process, used with in vitro cultivation, provides for precise identification of cultured organisms
Lyme disease in humans is caused by Borrelia burgdorferi sensu lato, organisms that
are known to attach to collagen in the body. The use of a matrix containing collagen
as a part of the culture composition has given us the ability to cultivate Borrelia
burgdorferi, B. afzelii, and B. garinii from the bloodstream using artificial media. The
cultured Borrelia is identified by immunostaining using polyclonal and monoclonal
antibodies. In order to distinctly differentiate the organisms from the collagen of this
matrix that could be observed as background in the staining process, we developed
an immunostaining procedure using polyclonal and monoclonal antibodies in
combination with rhodamine fibronectin. The culture samples from both control
organisms and patient samples were tested using the new immunostaining protocol.
Results showed clear delineation of organisms compared to the collagen pieces
gathered in the harvesting process. This new immunostaining process, used with in
vitro cultivation, provides for precise identification of cultured organisms.
http://www.advanced-lab.com/news/RF_Publication.pdf
are known to attach to collagen in the body. The use of a matrix containing collagen
as a part of the culture composition has given us the ability to cultivate Borrelia
burgdorferi, B. afzelii, and B. garinii from the bloodstream using artificial media. The
cultured Borrelia is identified by immunostaining using polyclonal and monoclonal
antibodies. In order to distinctly differentiate the organisms from the collagen of this
matrix that could be observed as background in the staining process, we developed
an immunostaining procedure using polyclonal and monoclonal antibodies in
combination with rhodamine fibronectin. The culture samples from both control
organisms and patient samples were tested using the new immunostaining protocol.
Results showed clear delineation of organisms compared to the collagen pieces
gathered in the harvesting process. This new immunostaining process, used with in
vitro cultivation, provides for precise identification of cultured organisms.
http://www.advanced-lab.com/news/RF_Publication.pdf
advanced-lab.com
New research from Norway 1 out of 6 blood donors tested positive for antibodies for Borrelia : Ny forskning på flått
New research from Norway 1 out of 6 blood donors tested positive for antibodies for Borrelia
Flåtten
har flere svin på skogen enn først antatt. Rundt én av seks blodgivere
bar antistoffer mot borrelia. Mange visste ikke at de hadde vært
smittet.
nrk.no|Par NRK
Two Takes on Lyme -
Almost 40 years after Lyme disease emerged, scientists are still unraveling the mysteries of...
magazine.jhsph.edu|Par Mike Smith
Nervous System Lyme Disease. -
Infect Dis Clin North Am. 2015 Jun;29(2):241-253. doi: 10.1016/j.idc.2015.02.002. REVIEW
ncbi.nlm.nih.gov|Par Halperin JJ
LOOKING AT LYME DISEASE - MSIDS: ME/CFS OUTSIDE THE BOX
Mis diagnosed as Fibromyalgia, ME/CFS,...
lookingatlyme.blogspot.com
Carte interactive des manifestations WWLP 2015 en France
Carte interactive des manifestations WWLP 2015 en France
La carte est cliquable en lien : http://u.osmfr.org/m/41275/
Des précisions peuvent être ajoutées de même que des points de rassemblements de dernières minutes.
Carte interactive des rassemblements
La carte est cliquable en lien : http://u.osmfr.org/m/41275/
Des précisions peuvent être ajoutées de même que des points de rassemblements de dernières minutes.
Carte interactive des rassemblements
Education Key to Stop Tick-Borne Illnesses ( + Dr R Horowitz's point of view )
Ticks
are out in full force this year, especially on Cape Cod and Martha's
Vineyard, so education and prevention of tick-borne diseases is
essential. We also need to have local health departments check ticks
regularly for changing patterns of co-infections, as diseases like
Tularemia are now being found in high numbers of ticks on the Cape.
Unless a health care provider was made aware of the risk for a disease
like Tularemia from a local tick bite, it would not normally be an
infection most doctors would consider in their differential diagnosis
if a patient came in with fatigue, fever, swollen lymph nodes, and a
headache. "There have been perhaps 130 cases of tularemia on the
Vineyard over the last 15 years, accounting for about 10 per cent of
nationally reported cases. Symptoms typically include an ulcer at the
site of the infection, swollen lymph glands, fever, chills, headache and
exhaustion". Other manifestations of Tularemia include oculoglandular
manifestations (conjunctivitis and swollen lymph nodes) as well as a
typhoidal form that can cause diarrhea. Several tick-borne infections
like Borrelia hermsii (relapsing fever), Ehrlichiosis and Rocky Mountain
Spotted Fever can also cause diarrhea, (with other G.I.
manifestations), acting as "great imitators", so health care providers
need to be on the alert for atypical manifestations of tick-borne
illnesses. Many patients that I see with Lyme-MSIDS who have been sick
for years suffer from Lyme and multiple tick-borne infections
simultaneously, accounting in part for the failure of short term
therapies. I discuss Tularemia and its various manifestations on pages
128 to 130 of "Why Can't I Get Better?". http://vineyardgazette.com/…/education-key-stop-tick-borne-…
Sam
Telford and Dick Johnson arrived at South Beach in the early afternoon
Wednesday in long-sleeved shirts and pants tucked into their socks. Mr.
Telford, a...
vineyardgazette.com
Ce maudit mot "déni" - R B-L F cimt
La signification de ce terme déni et spécialement quand il est employé pour la borréliose de Lyme
reseauborreliose.fr|Par H2o /ReBL
Maladie de Lyme : reconnaître la lésion typique de l’infection
La
maladie de Lyme fait peur parce qu'on ne sait pas la prévenir et parce
qu'on sait très mal la prendre en charge. Associée à la piqûre d'une
tique infectée par la...
medisite.fr
Warning as Dunfermline vet contracts disease after being bitten by tick
A DUNFERMLINE vet who contracted Lyme disease after being bitten by a tick is urging people to spread...
archive.dunfermlinepress.com
Is Lyme Diseases Killing Your Relationships?
Alix
Mayer earned an MBA at the Kellogg Graduate School of Management at
Northwestern, and spent nearly a decade in research and strategy for
Fortune ...
lymeninja
USING ENZYMES TO OVERCOME HASHIMOTO’S
"Bad
digestion is at the root of all evil"- said Hippocrates, the ancient
Greek physician who is considered the father of medicine modern
medicine. Although he was born in 460 BC, I think he was...
thyroidpharmacist.com
With bipartisan support, Lyme research bill moves forward
Measure incorporated into larger medical research bill approved unanimously by House committee
www.poughkeepsiejournal.com
Tic-Kit - Tick Testing
A newer option for testing ticks for various microbes. https://www.tic-kit.com/
Canada Sees An Increase In Lyme Disease As Climate Change Brings Ticks Up North
There has been increase in Lyme disease as ticks move north due t global warming
ibtimes.com.au|Par Honey George
Words of wisdom from Thalía regarding Lyme disease |
“They
didn’t care what I said” she wrote in the memoir. “It was as if I was
talking to a wall. I continued to feel like I had been run over by a
truck that had dragged me for a thousand miles, along with a steamroller
that had crushed every last bone in my body. I literally thought I was
dying.”
Words
of wisdom from Thalía regarding Lyme disease Monday Apr 13, 2015
12:08AM UTC Feature, News, Photos May is Lyme Disease Awareness Month,
a...
thaliaesmivida.com
Posttreatment Lyme Disease Syndrome - Infectious Disease Clinics
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full...
id.theclinics.com
ILADS - End Lyme disease epidemic through education, awareness & physican training.
ILADS'
vision: a world where no one is denied appropriate diagnosis and
treatment of Lyme disease, where families are not ruined financially,
and where no one lives a...
ilads.org
FDA looks at Babesia blood donor screening
Currently,
Babesia microti is the highest-ranking pathogen that is transmitted by
blood transfusion in the U.S. for which no donor screening is available,
according...
outbreaknewstoday.com
Tick Bite Changed My Life Forever:
On
12-12-12, HuffPost LIVE produced by The Huffington Post a video
interview and article with Wayne Connell, the founder and president of
the Invisible Disabilities...
sherriconnell.com|Par Sherri
Dr Horowitz Lyme Disease and Chronic Illness |
Over 900,000 people or higher are infected with Lyme disease in America.
lymetube.com
Das sollten Sie wissen: 34 erstaunliche Zecken-Fakten!
Die Zecke ist extrem gefährlich, zäh und trotzdem faszinierend. Diese 34 erstaunliche Fakten über die Zecke sprechen für sich!
zeckenrollen.de
Four decades after its discovery, Lyme disease still confounds doctors, patients
Heated
debate over Lyme disease is still going strong 40 years after the late
Dr Wilhelm Burgdorfer first identified the bacteria in Lyme Connecticut
For many it...
www.newsworks.org|Par John Abbott for WHYY
We need to get federal bill H.R. 789 passed through Congress, so that there is the creation of an independent scientific committee which will objectively look at the science regarding the insensitivity of diagnostic Lyme testing, while reviewing the peer reviewed science showing persistence of borrelia and associated co-infections.
Feature Competing Interests Centers for Disease Control and Prevention: protecting the private good? BMJ 2015; 350 doi: http://dx.doi.org/10.1136/bmj.h2362
(Published 15 May 2015) Cite this as: BMJ 2015;350:h2362 Article
Related content Metrics Responses Peer review Jeanne Lenzer, associate
editor,…
bmj.com
from Dr. Richard Horowitz
Feature Competing Interests Centers for Disease Control and Prevention: protecting the private good? BMJ 2015; 350 doi: http://dx.doi.org/10.1136/bmj.h2362
(Published 15 May 2015) Cite this as: BMJ 2015;350:h2362 Article
Related content Metrics Responses Peer review Jeanne Lenzer, associate
editor,…
bmj.com
from Dr. Richard Horowitz
“The CDC does receive millions of dollars in industry gifts and funding, both directly and indirectly, and several recent CDC actions and recommendations have raised questions about the science it cites, the clinical guidelines it promotes, and the money it is taking.... funding of CDC took a turn in 1983, when the CDC was authorized to accept external “gifts” from industry and other private parties".
These
conflicts of interest were not widely disseminated until now. How was
this information received by medical leaders? "Industry funding of the
CDC has taken many doctors, even some who worked for CDC, by surprise.
Philip Lederer, an infectious diseases fellow at Massachusetts General
Hospital and Brigham and Women’s Hospital in Boston, Massachusetts, and a
former CDC epidemic intelligence service officer, told The BMJ he was
“saddened” to learn of industry funding".
Professional reactions to the news include Neil Calman, president and chief executive of the Institute for Family Health in New York, a large community health center network with over half a million patient visits a year. He said "The institute has relied on CDC guidance largely because of its prestige as an independent agency, free of industry relationships". Calman told The BMJ, “Industry funding undermines trust and introduces a bias in the presentation of results and treatment recommendations that is deplorable for a government agency. If the allegations of industry funding and influence are true, we will have to look very carefully at recommendations we are following now and those made in the future by the CDC.” Calman said, “Industry claims their scientific methodology ensures their studies are unbiased—just as the CDC claims money doesn’t affect their recommendations. Yet multiple studies clearly—and repeatedly—show that who sponsors a study, or issues a guideline, makes a difference.”
We certainly have seen this problem exist in guideline development with regards to Lyme and associated tick-borne disorders. We need to get federal bill H.R. 789 passed through Congress, so that there is the creation of an independent scientific committee which will objectively look at the science regarding the insensitivity of diagnostic Lyme testing, while reviewing the peer reviewed science showing persistence of borrelia and associated co-infections. Expanded insurance coverage may then be available for those suffering from undiagnosed and/or inadequately treated tick-borne disorders.
http://www.bmj.com/content/350/bmj.h2362
Professional reactions to the news include Neil Calman, president and chief executive of the Institute for Family Health in New York, a large community health center network with over half a million patient visits a year. He said "The institute has relied on CDC guidance largely because of its prestige as an independent agency, free of industry relationships". Calman told The BMJ, “Industry funding undermines trust and introduces a bias in the presentation of results and treatment recommendations that is deplorable for a government agency. If the allegations of industry funding and influence are true, we will have to look very carefully at recommendations we are following now and those made in the future by the CDC.” Calman said, “Industry claims their scientific methodology ensures their studies are unbiased—just as the CDC claims money doesn’t affect their recommendations. Yet multiple studies clearly—and repeatedly—show that who sponsors a study, or issues a guideline, makes a difference.”
We certainly have seen this problem exist in guideline development with regards to Lyme and associated tick-borne disorders. We need to get federal bill H.R. 789 passed through Congress, so that there is the creation of an independent scientific committee which will objectively look at the science regarding the insensitivity of diagnostic Lyme testing, while reviewing the peer reviewed science showing persistence of borrelia and associated co-infections. Expanded insurance coverage may then be available for those suffering from undiagnosed and/or inadequately treated tick-borne disorders.
http://www.bmj.com/content/350/bmj.h2362
CDC - Transmission - Bartonella
Bartonella
bacteria cause several diseases in humans. The three most common are
cat scratch disease, caused by B. henselae; trench fever, caused by B.
quintana; and Carrión's disease, caused by B. bacilliformis.
www.cdc.gov
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