Chlamydia pneumoniae specific intrathecal oligoclonal antibody response is predominantly detected in a subset of multiple sclerosis patients with progressive forms
These
findings suggest that an intrathecal production of anti–C. pneumoniae
IgG is part of humoral polyreactivity driven by MS chronic brain
inflammation. However, an intrathecal release of C. pneumoniae–specific
oligoclonal IgG can occur in a subset of patients with MS progressive
forms in whom a C. pneumoniae–persistent brain infection may play a
pathogenetic role.
