"Rather, the ability to now study CNS involvement in Lyme disease in mice should help Lyme researchers answer mechanistic questions and better understand the factors that lead to neurological involvement when it does turn up in Lyme disease patients – details such as what Borrelia strains or species are most likely to lead to neuroborreliosis, whether there are environmental influences that add to the burden, and what host factors might contribute to disease outcomes. If a patient presents with a particular Borrelia strain shown to invoke stronger CNS involvement in mouse than other varieties, that may warrant more aggressive treatment, for example.
“The mouse model is going to be really, really useful in developing a lot of testable hypotheses,” says Brissette, the answers to which can then help inform nonhuman primate studies as well as human trials."
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