Lyme
borreliosis, caused by the spirochete Borrelia burgdorferi sensu lato,
has grown into a major public health problem. We recently identified a
novel morphological form of B. burgdorferi, called biofilm, a structure
that is well known to be highly resistant to antibiotics. However, there
is no evidence of the existence of Borrelia biofilm in vivo; therefore,
the main goal of this study was to determine the presence of Borrelia
biofilm in infected human skin tissues. In summary, this is the first
study that demonstrates the presence of Borrelia biofilm in human
infected skin tissues."