"New Alzheimer’s Study Aims to Delay or Prevent Symptoms

"New Alzheimer’s Study Aims to Delay or Prevent Symptoms

Neuroscience News June 17, 2016
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Summary: A new study will test a promising drug aimed at preventing or delaying Alzheimer’s symptoms.
Source: USC.
The international trial co-managed by USC will test a drug in people who show no symptoms of the disease.
USC researchers announced Tuesday they will test a promising drug aimed at preventing or delaying the symptoms of Alzheimer’s disease.
The international study, jointly managed by the USC Alzheimer’s Therapeutic Research Institute (ATRI) and Janssen Research & Development, will test Janssen’s BACE inhibitors in people who are currently showing no symptoms.
The investigational drug aims to block an enzyme involved in the generation of the amyloid peptide, a toxic molecule believed to play an essential role in causing Alzheimer’s.
“We are now looking at the stage of Alzheimer’s that precedes even mild symptoms,” said Paul Aisen, founding director of USC ATRI and professor of neurology at the Keck School of Medicine of USC. “It is our view that drugs such as BACE inhibitors may be most effective at the earliest stages of the disease.”
USC ATRI’s role in the study is funded by a new contract with Janssen. USC ATRI, located in San Diego, and Janssen will provide joint oversight for the study; in addition, ATRI will manage study activities at sites in the United States and Canada. Study sites in other countries will be managed by Quintiles.
“There is a lot of optimism that research may be ushering in a new era in Alzheimer’s drug development,” said Gary Romano, head of Alzheimer’s clinical development at Janssen. “We may be able to treat the disease using interventions before it becomes advanced, much like you treat high cholesterol to mitigate the risk of heart attacks.”
Trial details
This is a phase 2/3 randomized, double-blind, placebo-controlled, parallel group, multicenter study in people across North America, Europe, Japan and Australia who have evidence of brain amyloid accumulation but are asymptomatic."