Translation of the interview prof Perronne gave to the magazine Paris-Match this week. (Quick translation, so sorry if mistakes)
Things-they-are-a-movin' in France this year !!
Many illnesses called auto-immune or inflammatory have an infectious component.
Paris Match: Why are the effects of the Lyme bacteria, Borrelia burgdorferi, so poorly understood in France?
Pr Christian Perronne: As far back as 1920, a microbiologist from the
Pasteur Institute, Nobel Prize winner Charles Nicolle, had already
written about borrelias; many inflammatory and degenerative illnesses
are due to microbes hidden deep inside tissues and cause “unapparent
(stealth) infections”. If antibiotic treatment does not always work, it
is because parasites and viruses are also present mixed in with the
bacteria transmitted by arthropods and insects, such as ticks.
But,
after WWII, an “antimicrobial trend” emerges. In the USA, an
operational Head of Public Health declares that infectious diseases are
“a thing of the past, since we can now rely on hygiene, vaccinations and
antibiotics”. His words “contaminate” our own Public Health officials:
infectious diseases are considered to be a thing of the past. We are
entering the era of genetic and immunologic diseases, an approach that
still prevails today.
PM: What difficulties did you encounter trying to give microbes the role you think they deserve?
CP: Thirty years ago, I discovered that I could cure some auto-immune
illnesses using anti-infectious cocktails. I set up official research
protocols to evaluate the efficacy of my treatments. But specialists of
auto-immune diseases stopped patients who were volunteers, from
participating in my studies saying “it was charlatanism”!
As a
result, medical practitioners are not allowed to prescribe antibiotics
when “the diagnosis is unclear”, and if they do they risk being
deregistered by the “ Conseil de l’Ordre” (Council of the College of
Physicians). This is what happened to Dr Bottero in Nyons (Drôme), one
of the pioneers in France, who started bringing relief to autistic
children, to people with schizophrenia using antibiotics. Chronic Lyme
borreliosis is one of the possible causes of serious illnesses like
Multiple Sclerosis, Alzheimer’s, Parkinson’s... More than 800 symptoms
are due to the borrelias.
PM: In France, nobody knows of the connection between Alzheimer’s and borreliosis...
That’s right! A researcher from the INSERM (Institute for Health and
Medical Research in France), insisted that to consider a possible
infectious link for Alzheimer’s Disease was ludicrous! Yet, a team of
researchers in Philadelphia has, once again, proved a link between
certain forms of Alzheimer’s and borrelias. The problem, when we are
dealing with chronic illnesses, is that some patients are cured when
given antibiotics or antiparasitics, whereas others do not respond at
all, the likely reason being that viral factors can also be at play.
PM: you mean that Lyme borreliosis is not the sole culprit?
That’s right, I am of the opinion that most chronic illnesses that have
been given the labels of “inflammatory”, “auto-immune” or
“degenerative” have an infectious component. It is that infectious
component which triggers or fuels the illness.
PM: How can patients find help?
If you have an erythema migrant (the typical early Lyme circular rash),
the patient must demand a prescription for antibiotics from his or her
treating physician, and the official recommended dose must be prescribed
(amoxicilline 4g/day for 2 to 3 weeks). For more advanced forms of the
illness, the only reliable diagnostic method is a trial treatment with
antibiotics: if the antibiotics work, it means infection is present.
Since blood tests do not detect these bacterias in all cases, French
doctors are not allowed to give anti-infectious treatments on the basis
of the history and symptoms of the patient. It is not so everywhere,
things may differ if we cross our borders...
In Germany, for
example, tests are much more sensitive. Many French patients go there to
get treatment. In Germany doctors can give higher doses and longer
courses of antibiotics without getting into trouble from health
authorities. In France, chronic illnesses are diagnosed according to
their symptoms. No causes are looked for. Yet we know that there may be
an overlap in many illnesses. I once had a patient who was diagnosed as
having Rheumatoid Arthritis in Nantes and Multiple Sclerosis in Angers!
Lyme borreliosis can mimic both illnesses.
PM: Are there no reliable tests in France to detect borreliosis and associated infections?
CP: Only at veterinarians. They use the concept of “unapparent
(stealth) infection”. But such tests are not authorised for human use.
One laboratory did use these tests with a few patients, another doctor
reported him and he nearly had to close down his practice as a
disciplinary measure! The current tests here are performed using a 30
year-old American strain. They do not take into account the biodiversity
of this very diverse bacterial type.
PM: You teach at Paris-Versailles-Saint-Quentin University, do you inform your students of the effects of this disease?
CP: I do, students tell me that Lyme is a disease that has been
invented by the Internet. They are being told not to bother with
patients that have negative serologies, nor with the ones who have “too
many symptoms”, or to send them to a psychiatric ward!
PM: What is slowing down research?
CP: Ten years ago, few people knew of Lyme disease in France. Yet I had
published a study that showed that I cured 80 out of 100 patients, but
clinical studies take a long time and they are costly, especially when
the cause of the pathology is multifactorial. The pharmaceutical
industry could finance tests on stealth (unapparent) infections and
their treatments. Much money could be saved in health expenses, chronic
illnesses cost society a lot of money, and not only Lyme disease!