Clinical effects of fluconazole in patients with neuroborreliosis.
Schardt FW.Betriebsarztliche Untersuchungsstelle, Bayerische Julius-Maximilians-Universitat, Wurzburg, Germany.
Fritz.Schardt@mail.uni-wuerzburg.de
Eleven patients with neuro-borreliosis had been treated with 200 mg fluconazole daily for 25 days after an unsuccessful therapy with antibiotics.
At the end of treatment eight patients had no borreliosis symptoms and remained free of relapse in a follow-up examination one year later.
In the remaining four patients, symptoms were considerably improved. At the end of therapy immune reactivity (IgM+) disappeared in three patients.
Since borrelia spp. are almost exclusively localised intracellular, they may depend on certain metabolites of their eucaryotic host cell.
Inhibition of P450 and other cytochromes by fluconazole may incapacitate Borrelia upon longterm exposure.
http://www.immunesupport.com/library/showarticle.cfm/id/6431
A New Approach to Chronic Lyme Disease
05-11-2005By Jill Neimark
In May of this year I sat down at the beautiful Essex House on Central Park South, with a German physician specializing in internal medicine, Fritz Schardt. Dr. Schardt, who is associated with the University of Wurzburg in Germany, published an interesting pilot study in the European Journal of Medical Research in July of 2004 on the use of an antifungal drug, fluconazole, in treating chronic, advanced lyme disease. This pilot study examined 11 patients with chronic lyme. Dr. Schardt has slowly refined the protocol since then, and believes it holds great promise in treating this difficult condition-which is often misdiagnosed as chronic fatigue or fibromyalgia. Here follows our interview:
Jill Neimark (JN): What made you think of using diflucan, an antifungal, to treat lyme disease?
Dr. Fritz Schardt (FS): I was actually my first patient. I got lyme disease in 1989, and was given two weeks of doxycycline. Our country follows the protocols set by yours, so that's what is generally recommended. I now know that was very inadequate and I do not think doxycycline should be used in early lyme disease at all. It is only bacteriostatic, meaning it inhibits the bacteria but does not kill them.
JN: I know, the same thing happened to me. At the doses they recommend, it also does not penetrate the central nervous system. I had a fever, stiff neck and bullseye rash. The stiff neck means it was already in my nervous system. Therefore I probably needed six to eight weeks of doxycycline at double the dose I was given. Higher doses will penetrate the CNS.
FS: Right. I recommend penicillin in early lyme disease.
JN: Amoxicillin is given here. Is that what you recommend?
FS: No, that's broad spectrum, so you end up killing many bacteria, including necessary ones in your gut. I recommend smaller spectrum penicillins. The syphilis spirochete has not become resistant to penicillin, and there's good evidence that borrelia, the lyme spirochete, has not either. In Germany, we have cefalosporine, roxithromycin, cotrim-TMPO, and clarithromycin. These are all good choices. They should still be taken for 20-30 days.
JN: Okay, well, you took doxycycline so you ended up with chronic lyme disease. What happened then?
FS: I was sick for 18 months. I was given intravenous rocephin several times. I would feel better, but then once I stopped taking the antibiotics, I relapsed. I was often bedridden and I thought I was ready for the wheelchair. Then, I developed a fungal infection, possibly because of all the antibiotics. So I was put on diflucan. This was around 1990. It was a new drug that was being used mainly for opportunistic fungal infections in AIDS patients.
JN: And what happened?
FS: I got better. But I only stayed on it for two weeks at first, and then I got worse again. So I went back on it for 30 days, and I got well.
JN: What was the dose?
FS: I took 100 milligrams twice a day. JN: Are you completely well?
FS: I am very active and energetic and I feel quite well. I have since competed in athletic events and won them. However, I do have an occasional heart arrhythmia that I believe may be due to permanent damage from the spirochete.
JN: Tell me your reasoning as to why diflucan might work in chronic lyme.
FS: There are several reasons. First of all, it inhibits an enzyme called cytochrome P45O. This is an enzyme that your liver, for instance, uses to detoxify chemicals and drugs. Borrelia has a very primitive p45O defense, so if you inhibit it, it is easily weakened. Therefore I believe that diflucan inhibits the growth and replication of borrelia. It does not necessarily kill it. In addition, it penetrates well into the cells and into the nervous system and brain, where borrelia may hide.
JN: What is your current protocol?
FS: I recommend 200 milligrams a day, for 50 days. There are now 200 milligram pills available, so once a day is fine. Then I recommend 20-30 days of any of the penicillins I mentioned. You may have to go through several cycles of this protocol. You must also be very aware of other drugs that act on the p45O enzyme system, specifically a subset that inhibits CYP3A4. You should not be taking any of these drugs at the same time as you take diflucan.
JN: What are some of these drugs?
FS: There are many, and it's best to check with your doctor. Some common ones are erythromycin, amitryptylin, midazolam, Lovastatin, and others.
JN: I hate antibiotics. Do you have to take the penicillin?
FS: I understand, many lyme patients come to hate antibiotics because they have to take so many of them for so many years and are still ill. In fact, I also was made ill by the antibiotics.
JN: They really disrupt your digestion. FS: Right, that was my problem.
FS: I believe in the narrow-spectrum penicillins for borrelia, not the cyclines.
JN: What about 9 months?
FS: That remains to be seen. Perhaps, like tuberculosis, some patients will need to be on diflucan at least six months or more. Borrelia is a very sophisticated organism, and one of the few bacterium with two cell membranes. There is much we still have to learn about it.
(c) Jill Neimark, 2005. The mission of Lymeinfo is to keep you informed of issues that might be of interest to Lyme disease patients. Postings are not meant to imply that we agree with the content of all items we distribute
