Relationship of Inflammation and Autoimmunity to Psychiatric Sequelae in Lyme Disease
Robert C. Bransfield, MD, DLFAPA
Read Full Text Article
Psychiatric Annals
September 2012 - Volume 42 · Issue 9: 337-341
DOI: 10.3928/00485713-20120906-07
Abstract
CME Educational Objectives
1. Gain a better understanding of the pathophysiology of Lyme disease and other tick-borne diseases.
2. Learn to understand how a sequence of immune-mediated events in Lyme disease and other tick-borne disease can result in psychiatric symptoms.
See Also
The Relationship Between Obesity and Depression Among ...
'Severity' in Psychiatric Disorders
Inflammation in the Psychiatric Manifestations of Fibromyalgia ...
3. Recognize that infection and immune reactions in the body can affect the brain.
The causative spirochete of Lyme disease, Borrelia burgdorferi, is the most common human tick-borne pathogen in the Northern hemisphere. It is also probably the most complex bacteria known, as it has 132 genes and 21 plasmids, with 90% of this genetic material unrelated to any known bacteria.
LYD/TBD is associated with multisystemic symptoms, including psychiatric symptoms. Currently, there are 240 peer-reviewed articles demonstrating the association between LYD/TBD and psychiatric symptoms.
The most common mental symptoms include fatigue; nonrestorative sleep; impairments of executive functioning, attention, memory, and processing speed; sensory hyperacusis; and low frustration tolerance, irritability, depression, and anxiety.
Psychiatric symptoms are more significant with Babesia and Bartonella coinfections. A combination of our current limitations in understanding this disease, misinformation regarding this disease, and the failure to diagnose and treat it in the early stages results in a significant burden of psychiatric illness associated with LYD/TBD.
AUTHORS
Robert C. Bransfield, MD, DLFAPA, is a Clinical Associate Professor, Robert Wood Johnson UMDNJ Medical School.
Address correspondence to: Robert C. Bransfield, MD, DLFAPA, 225 Highway 35, Red Bank, NJ 07701; fax: 732-741-5308; email: Bransfield@comcast.net.
Disclosure: Dr. Bransfield has no relevant financial relationships to disclose.
doi: 10.3928/00485713-20120906-07
Psychiatric Annals
September 2012 - Volume 42 · Issue 9: 337-341
DOI: 10.3928/00485713-20120906-07
Abstract
CME Educational Objectives
1. Gain a better understanding of the pathophysiology of Lyme disease and other tick-borne diseases.
2. Learn to understand how a sequence of immune-mediated events in Lyme disease and other tick-borne disease can result in psychiatric symptoms.
See Also
The Relationship Between Obesity and Depression Among ...
'Severity' in Psychiatric Disorders
Inflammation in the Psychiatric Manifestations of Fibromyalgia ...
3. Recognize that infection and immune reactions in the body can affect the brain.
The causative spirochete of Lyme disease, Borrelia burgdorferi, is the most common human tick-borne pathogen in the Northern hemisphere. It is also probably the most complex bacteria known, as it has 132 genes and 21 plasmids, with 90% of this genetic material unrelated to any known bacteria.
LYD/TBD is associated with multisystemic symptoms, including psychiatric symptoms. Currently, there are 240 peer-reviewed articles demonstrating the association between LYD/TBD and psychiatric symptoms.
The most common mental symptoms include fatigue; nonrestorative sleep; impairments of executive functioning, attention, memory, and processing speed; sensory hyperacusis; and low frustration tolerance, irritability, depression, and anxiety.
Psychiatric symptoms are more significant with Babesia and Bartonella coinfections. A combination of our current limitations in understanding this disease, misinformation regarding this disease, and the failure to diagnose and treat it in the early stages results in a significant burden of psychiatric illness associated with LYD/TBD.
AUTHORS
Robert C. Bransfield, MD, DLFAPA, is a Clinical Associate Professor, Robert Wood Johnson UMDNJ Medical School.
Address correspondence to: Robert C. Bransfield, MD, DLFAPA, 225 Highway 35, Red Bank, NJ 07701; fax: 732-741-5308; email: Bransfield@comcast.net.
Disclosure: Dr. Bransfield has no relevant financial relationships to disclose.
doi: 10.3928/00485713-20120906-07
- Brandaktuell aus den USA - CME Article
Relationship of Inflammation and Autoimmunity to Psychiatric Sequelae in Lyme Disease
Robert C. Bransfield, MD, DLFA...
Relationship of Inflammation and Autoimmunity to Psychiatric Sequelae in Lyme Disease
Robert C. Bransfield, MD, DLFA...
